Activation of Adenylyl Cyclase Reduces TGF-β Profibrotic Response in Osteoarthritic Fibroblast-Like Synoviocytes
نویسندگان
چکیده
منابع مشابه
Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes
Fibroblast activation protein (FAP), as described so far, is a type II cell surface serine protease expressed by fibroblastic cells in areas of active tissue remodelling such as tumour stroma or healing wounds. We investigated the expression of FAP by fibroblast-like synoviocytes (FLSs) and compared the synovial expression pattern in rheumatoid arthritis (RA) and osteoarthritis (OA) patients. S...
متن کاملEvaluation of tendon healing using fibroblast like synoviocytes in rabbits: A biomechanical study
Tendon never restores the complete biological and mechanical properties after healing. Several techniques are available for tissue-engineered biological augmentation for tendon healing like stem cells. Recently, synovium has been investigated as a source of cells for tissue engineering. In the present study, we investigated potentials of fibroblast like synoviocytes (FLSs) in tendon healing. Si...
متن کاملSimvastatin Induces Apoptosis of Fibroblast-Like Synoviocytes
BACKGROUND Statins (3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors) exert favorable effects on lipoprotein metabolism, but appeared to possess anti-inflammatory properties among others, as suggested by their ability to inhibit collagen-induced arthritis in mice. Their activity in fibroblast-like synovial cells (FLS) has not yet been studied. OBJECTIVES To evaluate the effect of varying d...
متن کاملIn Vitro Evaluation of Equine Fibroblast-Like Synoviocytes Viability Treated with Doxycycline
Objective- The purpose of present study was to investigate the viability of equine fibroblast-like synoviocytes (FLSs) treated with doxycycline. Design- Experimental study. Sample population- FLSs from metacarpophalangeal joints of six skeletally mature horses. Methods- FLSs were established from synovial fluids of healthy joints. The cells were treated with different concentr...
متن کاملTGF-β signaling in the kidney: profibrotic and protective effects.
Transforming growth factor-β (TGF-β) is generally considered as a central mediator of fibrotic diseases. Indeed, much focus has been placed on inhibiting TGF-β and its downstream targets as ideal therapeutic strategies. However, pharmacological blockade of TGF-β has not yet translated into successful therapy for humans, which may be due to pleiotropic effects of TGF-β signaling. Equally, TGF-β ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2017
ISSN: 1063-4584
DOI: 10.1016/j.joca.2017.02.465